What is ICP-MS method development?
ICP-MS method development builds the full analytical workflow — sample preparation, dilution, calibration, internal standards, interference control, blank control, and QC rules — for a specific matrix and set of target elements. For semiconductor micro-contamination analysis, method development is often more important than instrument measurement alone.
Can ICP-MS methods reach sub-ppt?
Depending on matrix, target elements, sample preparation, blank control, instrument configuration, and lab conditions, some applications can be developed to sub-ppt or ppt level. The actual achievable level is confirmed through method development and validation results — instrument specs alone are not enough.
Which semiconductor matrices suit ICP-MS method development?
Common matrices include UPW, HF, HCl, HNO3, H2SO4, H3PO4, NH4OH, TMAH, IPA, electronic-grade solvents, cleaning solutions, etchants, slurry, plating bath, and other process chemicals. The actual method is confirmed against matrix concentration, target elements, and instrument conditions.
What does ICP-MS method transfer cover?
Method transfer typically includes method-condition documentation, sample-prep steps, calibration and QC design, blank-control recommendations, interference-troubleshooting focus areas, SOP files, and customer-lab deployment support. The actual scope is confirmed per project.
Why does semiconductor ICP-MS analysis need special blank control?
At ppt or sub-ppt levels, containers, reagents, environment, operating procedures, and consumables can all contribute to background. Without solid blank control, even adequate instrument sensitivity may fail to deliver credible low-concentration results.
How does ICP-MS/MS method development differ from ICP-MS?
ICP-MS/MS can handle some polyatomic interferences via reaction or collision mechanisms, which can help for certain matrices and elements. Whether ICP-MS/MS is needed still depends on matrix, target elements, interference situation, and the customer's instrument.
Can Ultra-trace Analytics transfer the method to our own lab?
Yes — per project we can discuss method transfer and deployment support, including SOP, QC design, method-condition documentation, troubleshooting, and customer-lab condition comparison. The actual support is confirmed against your instrument, lab conditions, and project scope.
What information do you need before starting method development?
Please share sample matrix, SDS, target elements, target concentration or specifications, current method, current issues, instrument model, whether ICP-MS/MS is available, and desired deliverables (e.g. SOP, validation data, or technology transfer).